LRPAP1 Rabbit Polyclonal Antibody

SKU TA323026

Anti-LRPAP1 Rabbit Polyclonal Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: WB: 500-2000; WB positive control: 293T cells and fetal kidney tissue; IHC: 50-200; Positive control: Human colon cancer; Predicted cell location: Cytoplasm
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 344-357 amino acids of Human low density lipoprotein receptor-related protein associated protein 1
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 41 kDa
• Gene Name: LDL receptor related protein associated protein 1
• Database Link:
  NP_002328
  P30533
• Background: Low density lipoprotein receptor-related protein associated protein 1?also known as?LRPAP1?or?RAP?is a chaperone?protein?which in humans is encoded by the LRPAP1?gene. LRPAP1 is involved with trafficking of certain members of the LDL receptor family including LRP1 and LRP2. It is a glycoprotein that binds to the alpha-2-macroglobulin receptor; as well as to other members of the low density lipoprotein receptor family. It acts to inhibit the binding of all know ligands for these receptors; and may prevent receptor aggregation and degradation in the endoplasmic reticulum; thereby acting as a molecular chaperone. It may be under the regulatory control of calmodulin; since it is able to bind calmodulin and be phosphorylated by calmodulin-dependent kinase II.
• Synonyms: A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP; MYP23; RAP

Reference Data

• Protein Families: Druggable Genome, Transmembrane