VNN2 Rabbit Polyclonal Antibody

SKU TA322714

Anti-VNN2 Rabbit Polyclonal Antibody

Product Data

• Application: WB
• Recommended Dilution: WB: 200-1000; WB positive control: K562 and hela cells
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 389-401 amino acids of human vanin 2
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 59 kDa
• Gene Name: vanin 2
• Database Link:
  NP_004656
  O95498
• Background: This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other; and also with biotinidase. The family includes secreted and membrane-associated proteins; a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins; however; they possess pantetheinase activity; which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to; and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Synonyms: FOAP-4; GPI-80

Reference Data

• Protein Families: Druggable Genome, Transmembrane