PRCP Rabbit Polyclonal Antibody

CAT#: TA322678

Anti-PRCP Rabbit Polyclonal Antibody

Product Images

Gel: 10%SDS-PAGE Lysate: 50 μg Lane 1-3: SKOV3 cells A549 cells human liver cancer tissue Primary antibody: TA322678 (PRCP Antibody) at dilution 1/100 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 5 minutes

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA322678 (PRCP Antibody) at dilution 1/15 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA322678 (PRCP Antibody) at dilution 1/15, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA322678 (PRCP Antibody) at dilution 1/15 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA322678 (PRCP Antibody) at dilution 1/15, treated with fusion protein. (Original magnification: ×200)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: SKOV3, A549 cells and human liver cancer tissue
  IHC: 25-100
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 46-317 amino acids of human prolylcarboxypeptidase (angiotensinase C)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 56 kDa
• Gene Name: prolylcarboxypeptidase
• Database Link:
  NP_005031
  Entrez Gene 72461 MouseEntrez Gene 5547 Human
  UniProt ID P42785
• Background: The protein encoded by this gene is a lysosomal prolylcarboxypeptidase; which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II; III and des-Arg9-bradykinin. The cleavage occurs at acidic pH; but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II; one of the substrates of this enzyme; in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
• Synonyms: HUMPCP; PCP

Reference Data

• Protein Families: Druggable Genome, Protease, Transmembrane