PRCP Rabbit Polyclonal Antibody

CAT#: TA322678

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Anti-PRCP Rabbit Polyclonal Antibody

USD 380.00

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    • 100 ul

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Product Data
Applications IHC, WB
Recommended Dilution ELISA: 1:1000-2000, WB: 1:200-1000, IHC: 1:25-100
Reactivity Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fusion protein corresponding to a region derived from 46-317 amino acids of human prolylcarboxypeptidase (angiotensinase C)
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 56 kDa
Gene Name prolylcarboxypeptidase
Background The protein encoded by this gene is a lysosomal prolylcarboxypeptidase; which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II; III and des-Arg9-bradykinin. The cleavage occurs at acidic pH; but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II; one of the substrates of this enzyme; in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Synonyms HUMPCP; PCP
Reference Data
Protein Families Druggable Genome, Protease, Transmembrane
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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