OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

NGAL (LCN2) Rabbit Polyclonal Antibody

Be the first to review this product
SKU
TA322583
Anti-LCN2 Rabbit Polyclonal Antibody
Size:
100 ul
Conjugation:
Unconjugated
  $305.00
2 Weeks*
Bulk/Customize

Frequently Bought Together (3)

TA811000S beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control 30 ul
$200.00
LY417226 Transient overexpression lysate of lipocalin 2 (LCN2) (as WB positive control) 100 ug
$436.00
TP307685 Recombinant protein of human lipocalin 2 (LCN2), 20 µg
20 ug
$737.00

View other "NGAL or NM_005564" antibodies

Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution WB: 1000-5000
WB positive control: Human liver cancer tissue
IHC: 50-200
Positive control: Human breast cancer
Predicted cell location: Cytoplasm
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide peptide corresponding to a region derived from 60-73 amino acids of human lipocalin 2
Buffer PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 23 kDa
Gene Name lipocalin 2
Database Link
Background Iron-trafficking protein involved in multiple processes such as apoptosis; innate immunity and renal development. Binds iron through association with 2;5-dihydroxybenzoic acid (2;5-DHBA); a siderophore that shares structural similarities with bacterial enterobactin; and delivers or removes iron from the cell; depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor; leading to release of iron and subsequent increase of intracellular iron concentration. In contrast; association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore; iron chelation and iron transfer to the extracellular medium; thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis; while iron-free form decreases intracellular iron levels; inducing expression of the proapoptotic protein BCL2L11/BIM; resulting in apoptosis. Involved in innate immunity; possibly by sequestrating iron; leading to limit bacterial growth.
Synonyms 24p3; MSFI; NGAL
Reference Data
Protein Categories Secreated Proteins
Protein Families Secreted Protein
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources

file-alt Citations

LCN2 Is a Potential Biomarker for Radioresistance and Recurrence in Nasopharyngeal Carcinoma
Zhang, Wang, Zeng et al
Front Oncol (2020) 10, 605777 DOI: 10.3389/fonc.2020.605777
Cited by 20
AI Summary: OriGene products, specifically the LCN2 Human cDNA ORF Clone (RC208349) and LCN2 shRNA plasmids (TG313423), were used in this study to manipulate LCN2 expression in nasopharyngeal carcinoma cell lines, enabling the authors to investigate the role of LCN2 in radioresistance and recurrence.
FigureFigureFigure
Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure
Marques, Prestes, Byars et al
J Am Heart Assoc (2017) 6 (6) DOI: 10.1161/JAHA.117.005971
AI Summary: OriGene contributed to this study by providing the anti-LCN2 Rabbit Polyclonal antibody (TA322583), which was used for immunohistochemistry to detect LCN2 expression in cardiac tissues.
Snippet: …Immunohistochemistry was performed using an anti-LCN2 Rabbit Polyclonal antibody (1:200 dilution, TA322583;OriGene Technologies, Rockville, MD), followed by the EnVision+System-HRP
IHC
Inhibition of FASN suppresses migration, invasion and growth in hepatoma carcinoma cells by deregulating the HIF-1α/IGFBP1 pathway
Gong, Shen, Yang et al
Int J Oncol (2017) 50 (3), 883-892 DOI: 10.3892/ijo.2017.3867
Cited by 51
AI Summary: OriGene products, specifically the FASN shRNA plasmid (Cat# TG311034) and HIF-1α antibody (Cat# TA500490), were used in this study to knock down FASN expression and detect HIF-1α protein levels, respectively, thereby enabling the investigation of how FASN inhibition affects hepatoma cell migration, invasion, and the HIF-1α/IGFBP1 pathway.
Showing 1-3 of 3 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products