RAMP3 Rabbit Polyclonal Antibody

CAT#: TA322549

Anti-RAMP3 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA322549 (RAMP3 Antibody) at dilution 1/40 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA322549 (RAMP3 Antibody) at dilution 1/40, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA322549 (RAMP3 Antibody) at dilution 1/40 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA322549 (RAMP3 Antibody) at dilution 1/40, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human ovarian cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 24-118 amino acids of human receptor (G protein-coupled) activity modifying protein 3
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: receptor (G protein-coupled) activity modifying protein 3
• Database Link:
  NP_005847
  Entrez Gene 56089 MouseEntrez Gene 56820 RatEntrez Gene 10268 Human
  UniProt ID O60896
• Background: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins; called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR; a receptor with seven transmembrane domains; can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor; depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein; CRLR functions as an adrenomedullin receptor.
• Synonyms: calcitonin receptor-like receptor activity modifying protein 3; receptor (calcitonin) activity modifying protein 3; receptor (G protein-coupled) activity modifying protein 3; receptor-activity-modifying protein 3; receptor activity modifying protein 3

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Vascular smooth muscle contraction