ABCB8 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | WB: 500-2000 WB positive control: Mouse heart tissue |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to a region derived from 394-693 amino acids of Human ATP-binding cassette sub-family B member 8 |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | ATP binding cassette subfamily B member 8 |
| Database Link | |
| Background | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1; MDR/TAP; MRP; ALD; OABP; GCN20; White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however; it may involve the compartmentalization and transport of heme; as well as peptides; from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes. |
| Synonyms | EST328128; M-ABC1; MABC1 |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | ABC transporters |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Exercise and Doxorubicin Modify Markers of Iron Overload and Cardiolipin Deficiency in Cardiac Mitochondria
Montalvo, Boeno, Dowllah et al
Int J Mol Sci (2023) 24 (9) DOI: 10.3390/ijms24097689
Montalvo, Boeno, Dowllah et al
Int J Mol Sci (2023) 24 (9) DOI: 10.3390/ijms24097689
Cited by 11
AI Summary: In this study, OriGene’s Cardiolipin Synthase 1 (CRLS1) antibody (Cat# TA327322) was used to assess protein expression levels, helping the authors demonstrate that exercise preconditioning rescues cardiolipin synthase 1 expression in cardiac mitochondrial subpopulations affected by doxorubicin treatment.
Exercise and Doxorubicin Modify Markers of Iron Overload and Cardiolipin Deficiency in Cardiac Mitochondria
Montalvo, Boeno, Dowllah et al
IJMS (2023) 24 (9), 7689 DOI: 10.3390/ijms24097689
Montalvo, Boeno, Dowllah et al
IJMS (2023) 24 (9), 7689 DOI: 10.3390/ijms24097689
Cited by 11
AI Summary: In this study, the OriGene ABCB8 antibody (TA322438) was used to assess protein expression related to mitochondrial iron handling, contributing to the investigation of how exercise and doxorubicin affect cardiac mitochondrial function.
Snippet: 4 °C with primary antibodies directed against GPX4 (ab125066, 1:1000);MFRN1 (Mitoferrin1, ab56134, 1:1000);SOD2 (ab68155, 1:1000);VDAC (ab14734, 1:1000) from Abcam;ABCB8 (TA322438, 1:1000) from Origene (Rockville, MD, USA);FtMt (PA530906, 1:500) from Invitrogen (Waltham, MA, USA);CRLS1 (14845-1-AP);and 1:1000 NDUFS3 (15066-1-AP, 1:1000) from Proteintech (Rosemont, IL, USA) diluted 1:1 in
Showing 1-2 of 2 papers.
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