MDC1 Rabbit Polyclonal Antibody

CAT#: TA322369

Anti-MDC1 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human brain tissue using TA322369 (MDC1 Antibody) at dilution 1/80 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human brain tissue using TA322369 (MDC1 Antibody) at dilution 1/80, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 100-300
  Positive control: Human brain
  Predicted cell location: Cytoplasm, Nucleus
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 1866-1881 amino acids of Human mediator of DNA-damage checkpoint 1
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: mediator of DNA damage checkpoint 1
• Database Link:
  NP_055456
  Entrez Gene 9656 Human
  UniProt ID Q14676
• Background: The protein encoded by this gene contains an N-terminal forkhead domain; two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs; and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
• Synonyms: NFBD1