ANKRD28 Rabbit Polyclonal Antibody

SKU TA322355

Anti-ANKRD28 Rabbit Polyclonal Antibody

Product Data

• Application: WB
• Recommended Dilution: WB: 500-2000; WB positive control: A549 cell lysate
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 1040-1053 amino acids of human ankyrin repeat domain 28
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 96 kDa
• Gene Name: ankyrin repeat domain 28
• Database Link:
  NP_056014
  O15084
• Background: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. ANKRD28 selectively regulated phosphorylation of hnRNP-K at ser284; an effect that was enhanced in vivo by an S1013A/S1017A double mutant; suggesting that ANKRD28 targets PP1 in a regulated manner to dephosphorylate hnRNP-K selectively at ser284.
• Synonyms: PITK; PPP1R65

Reference Data