AGBL2 Rabbit Polyclonal Antibody

CAT#: TA322178

Anti-AGBL2 Rabbit Polyclonal Antibody

Product Images

Gel: 6%SDS-PAGE Lysate: 40 μg Lane: 293T cell Primary antibody: TA322178 (AGBL2 Antibody) at dilution 1/200 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 1 minute

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  Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using TA322178 (AGBL2 Antibody) at dilution 1/25 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using TA322178 (AGBL2 Antibody) at dilution 1/25, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA322178 (AGBL2 Antibody) at dilution 1/25 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA322178 (AGBL2 Antibody) at dilution 1/25, treated with fusion protein. (Original magnification: ×200)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: 293T cell
  IHC: 25-100
  Positive control: Human gastric cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ATP/GTP binding protein-like 2
• Database Link:
  NP_079059
  Entrez Gene 79841 Human
  UniProt ID Q5U5Z8
• Background: Metallocarboxypeptidase that may play a role in the processing of tubulin. Knockdown of AGBL2 results in a failure of the cell to detyrosinate the C-terminal EEY region of a-tubulin and indicates that, it is a candidate for the long sought after tubulin tyrosine carboxypeptidase important in regulation of microtubule dynamics. RARRES1, its interacting partners AGBL2, Eg5/KIF11, another EEY bearing protein (EB1), and the microtubule tyrosination cycle are important in tumorigenesis and identify a novel area for therapeutic intervention.
• Synonyms: CCP2

Reference Data

• Protein Families: Druggable Genome