CLDN19 Rabbit Polyclonal Antibody

SKU TA322029

Anti-CLDN19 Rabbit Polyclonal Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: WB: 200-1000; WB positive control: Hepg2 and 293T cell; IHC: 10-50; Positive control: Human liver cancer; Predicted cell location: Cell membrane
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 186-200 amino acids of Human Claudin 19
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 23 kDa
• Gene Name: claudin 19
• Database Link:
  NP_683763
  Q8N6F1
• Background: The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space; through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia; hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars; macular colobomata; significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
• Synonyms: HOMG5

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction