ENPP7 Rabbit Polyclonal Antibody

CAT#: TA322002

Anti-ENPP7 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using TA322002 (ENPP7 Antibody) at dilution 1/40 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using TA322002 (ENPP7 Antibody) at dilution 1/40, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human colon cancer tissue using TA322002 (ENPP7 Antibody) at dilution 1/40 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human colon cancer tissue using TA322002 (ENPP7 Antibody) at dilution 1/40, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human prostate cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 290-305 amino acids of Human ectonucleotide pyrophosphatase/phosphodiesterase 7
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 52 kDa
• Gene Name: ectonucleotide pyrophosphatase/phosphodiesterase 7
• Database Link:
  NP_848638
  Entrez Gene 303729 RatEntrez Gene 339221 Human
  UniProt ID Q6UWV6
• Background: Ectonucleotide pyrophosphatase/phosphodiesterase family member 7?(E-NPP 7) also known as?alkaline sphingomyelin phosphodiesterase?(Alk-SMase) or?intestinal alkaline sphingomyelinase?is an?enzyme?that in humans is encoded by the?ENPP7?gene. Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity. Inhibited in a dose dependent manner by ATP; imidazole; orthovanadate and zinc ion. Not inhibited by ADP; AMP and EDTA. Detected in the colon (at protein level). Expressed in the duodenum; jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus; stomach and colon.
• Synonyms: 339221; ALK-SMase; E-NPP 7; NPP-7; NPP7

Reference Data

• Protein Pathways: Metabolic pathways, Sphingolipid metabolism