APAF1 Rabbit Polyclonal Antibody

CAT#: TA321993

Anti-APAF1 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using TA321993 (APAF1 Antibody) at dilution 1/25 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using TA321993 (APAF1 Antibody) at dilution 1/25, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA321993 (APAF1 Antibody) at dilution 1/25 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA321993 (APAF1 Antibody) at dilution 1/25, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human cervical cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 8-20 amino acids of Human apoptotic peptidase activating factor 1
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: apoptotic peptidase activating factor 1
• Database Link:
  NP_001151
  Entrez Gene 11783 MouseEntrez Gene 78963 RatEntrez Gene 317 Human
  UniProt ID O14727
• Background: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain; a caspase recruitment domain (CARD); and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP; this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein; releasing its mature; activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
• Synonyms: APAF-1; CED4

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Huntington's disease, p53 signaling pathway, Parkinson's disease, Small cell lung cancer