CHRFAM7A Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB:1/500-2000;IHC:1/25-100 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide peptide corresponding to a region derived from 32-46 amino acids of human CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 46 kDa |
| Gene Name | CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion |
| Database Link | |
| Background | The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7; which is located on chromosome 15 in a region associated with several neuropsychiatric disorders; is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed; and two variants exist; for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene; translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. |
| Synonyms | CHRNA7; CHRNA7-DR1; D-10 |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Ion Channels: Other, Transmembrane |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
YAP-Dependent BiP Induction Is Involved in Nicotine-Mediated Oral Cancer Malignancy
Chien, Chen, Hsu et al
Cells (2021) 10 (8) DOI: 10.3390/cells10082080
Chien, Chen, Hsu et al
Cells (2021) 10 (8) DOI: 10.3390/cells10082080
Cited by 25
AI Summary: In this study, the OriGene α7-nAChR antibody (TA321939) was used to investigate the role of α7-nAChR in nicotine-mediated signaling pathways contributing to oral cancer malignancy.
Snippet: BiP (610978), E-cadherin (610182), and ZO-1 (610966) from BD Biosciences, San Jose, CA, USA;fibronectin (ab32419) from Abcam, Cambridge, MA, USA;occludin (#71-1500) from Thermo Fisher, Pittsburgh, PA, USA;α7-nAChR (TA321939) from OriGene, Rockville Cached
Showing 1-1 of 1 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
