TRAF2 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 200-1000 WB positive control: Human normal liver tissue IHC: 25-100 Positive control: Human lung cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to a region derived from 351-496 amino acids of human TNF receptor-associated factor 2 |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | TNF receptor associated factor 2 |
| Database Link | |
| Background | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with; and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors; and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs); and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD; a TNF receptor associated apoptotic signal transducer; ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1; an apoptosis inhibitor possessing ubiquitin ligase activity; can unbiquitinate and induce the degradation of this protein; and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene; but the biological validity of only one transcript has been determined. |
| Synonyms | MGC:45012; TRAP; TRAP3 |
| Reference Data | |
| Protein Categories | Cytokines, Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Adipocytokine signaling pathway, Apoptosis, MAPK signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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