PIWIL2 Rabbit Polyclonal Antibody

CAT#: TA321862

Anti-PIWIL2 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human colon cancer tissue using TA321862 (PIWIL2 Antibody) at dilution 1/40 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human colon cancer tissue using TA321862 (PIWIL2 Antibody) at dilution 1/40, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA321862 (PIWIL2 Antibody) at dilution 1/40 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA321862 (PIWIL2 Antibody) at dilution 1/40, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human colon cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide peptide corresponding to a region derived from 107-120 amino acids of human piwi-like 2 (Drosophila)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: piwi like RNA-mediated gene silencing 2
• Database Link:
  NP_060538
  Entrez Gene 55124 Human
  UniProt ID Q8TC59
• Background: PIWIL2 belongs to the Argonaute family of proteins; which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization; which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes; germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Indirectly modulate expression of genes such as PDGFRB; SLC2A1; ITGA6; GJA7; THY1; CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed; acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors
• Synonyms: CT80; HILI; mili; PIWIL1L

Reference Data

• Protein Pathways: Dorso-ventral axis formation