PIWIL2 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC |
|---|---|
| Recommended Dilution | IHC: 25-100 Positive control: Human colon cancer Predicted cell location: Cytoplasm |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide peptide corresponding to a region derived from 107-120 amino acids of human piwi-like 2 (Drosophila) |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | piwi like RNA-mediated gene silencing 2 |
| Database Link | |
| Background | PIWIL2 belongs to the Argonaute family of proteins; which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization; which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes; germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Indirectly modulate expression of genes such as PDGFRB; SLC2A1; ITGA6; GJA7; THY1; CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed; acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors |
| Synonyms | CT80; HILI; mili; PIWIL1L |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Pathways | Dorso-ventral axis formation |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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