GDF15 Rabbit Polyclonal Antibody

CAT#: TA321674

Anti-GDF15 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA321674 (GDF15 Antibody) at dilution 1/150 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA321674 (GDF15 Antibody) at dilution 1/150, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 150-300
  Positive control: Human liver cancer
  Predicted cell location: Secreted
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 195-308 amino acids of human growth differentiation factor 15
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: growth differentiation factor 15
• Database Link:
  NP_004855
  Entrez Gene 9518 Human
  UniProt ID Q99988
• Background: Bone morphogenetic proteins (e.g.; BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF15 mRNA is most abundant in the liver; with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver; kidney; heart and lung.
• Synonyms: GDF-15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB

Reference Data

• Protein Families: Druggable Genome, Secreted Protein