GJB2 Rabbit Polyclonal Antibody

SKU TA321614

Anti-GJB2 Rabbit Polyclonal Antibody

Product Data

• Application: IHC
• Recommended Dilution: IHC: 100-300; Positive control: Human esophagus cancer; Predicted cell location: Cytoplasm, Cell membrane
• Reactivity: Human, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 212-227 amino acids of Human gap junction protein, beta 2, 26kDa
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: gap junction protein beta 2
• Database Link:
  NP_003995
  P29033
• Background: This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins; also known as connexins; purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels; the gap junction proteins are divided into two categories; alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual; recessive deafness.
• Synonyms: CX26; DFNA3; DFNA3A; DFNB1; DFNB1A; HID; KID; NSRD1; PPK

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane