DAP5 (EIF4G2) Rabbit Polyclonal Antibody

SKU TA321342

Anti-EIF4G2 Rabbit Polyclonal Antibody

Product Data

• Application: WB
• Recommended Dilution: WB: 500-2000; WB positive control: Hela and HepG2 cells
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 796-812 amino acids of Human Eukaryotic translation initiation factor 4 gamma 2
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 102 kDa
• Gene Name: eukaryotic translation initiation factor 4 gamma 2
• Database Link:
  NP_001409
  P78344
• Background: Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F); which is a cap binding protein complex that consists of three subunits: eIF4A; eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G; in addition; contains a binding site for eIF4E at the N-terminus. Unlike eIF4G; which supports cap-dependent and independent translation; this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
• Synonyms: AAG1; DAP5; NAT1; P97

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: Viral myocarditis