CRB2 Rabbit Polyclonal Antibody

SKU TA320165

Rabbit Polyclonal CRB2 Antibody

Product Data

• Application: ELISA, WB
• Recommended Dilution: CRB2 antibody can be used for detection of CRB2 by Western blot at 1 µg/mL.; Antibody validated: Western Blot in human,mouse, and rat samples. All other applications and species not yet tested.
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Rabbit polyclonal CRB2 antibody was raised against a 17 amino acid peptide near the center of human CRB2.
• Specificity: At least three isoforms of CRB2 are known to exist; this antibody will detect all three. CRB2 antibody is predicted to not cross-react with other members of the CRB family.
• Buffer: CRB2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: CRB2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 141 kDa
• Gene Name: crumbs 2, cell polarity complex component
• Database Link:
  NP_775960
  Q5IJ48
• Background: CRB2 Antibody: CRB2 (Crumbs homolog 2), like its homologs CRB1 and CRB3, is similar to the Drosophila crumbs protein and is expressed in retina, brain and kidney. Along with other proteins, the Crumbs proteins form a complex that help set up cell polarity in developing neuroepithelial cells. At the onset of neural specification, embryonic stem cells (ESCs) upregulate CRB2, which then localizes apically in neural rosettes. Gain- and loss-of-function studies of CRB2 have shown that CRB2 is essential for the stabilization of other polarity proteins. Unlike CRB1, mutations in CRB2 do not appear to play a role in retinitis pigmentosa or in Leber congenital amaurosis.
• Synonyms: FSGS9; VMCKD

Reference Data

• Protein Families: Transmembrane