CCDC141 Rabbit Polyclonal Antibody

CAT#: TA320162

Rabbit Polyclonal CCDC141 Antibody

Product Images

Western blot analysis of CCDC141 in SK-N-SH cell tissue lysate with CCDC141 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide

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  Immunohistochemistry of CCDC141 in mouse brain tissue with CCDC141 antibody at 5 ug/mL.

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  Immunofluorescence of CCDC141 in mouse brain tissue with CCDC141 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CCDC141 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CCDC141.
• Formulation: CCDC141 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: CCDC141 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: coiled-coil domain containing 141
• Database Link:
  NP_775919
  Entrez Gene 545428 MouseEntrez Gene 285025 Human
  UniProt ID Q6ZP82
• Background: CCDC141 Antibody: Coiled-coil domain-containing protein 141 (CCDC141), also known as CAMDI, is a recently identified disrupted in schizophrenia 1 (DISC1)-binding protein that also associates with myosin II. CCDC141 preferentially associates with phosphomyosin II and causes an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi led to severely impaired radial migration with disoriented chromosomes, suggesting that CCDC141 is required for radial migration through DISC1 and myosin II-mediated centrosome positioning during neuronal development.
• Synonyms: CAMDI