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TAB3 Rabbit Polyclonal Antibody

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SKU
TA320155
Rabbit Polyclonal TAB3 Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $640.00
5 Days*
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Specifications
Specifications
Product Data
Application IHC
Recommended Dilution IHC: 5 ug/mL
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen TAB3 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human TAB3.
Buffer TAB3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification TAB3 Antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name TGF-beta activated kinase 1/MAP3K7 binding protein 3
Database Link
Background TAB3 Antibody: TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
Synonyms MAP3K7IP3; NAP1
Reference Data
Protein Categories Cytokines, Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways NOD-like receptor signaling pathway
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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