LEMD2 Rabbit Polyclonal Antibody

CAT#: TA320148

Rabbit Polyclonal LEMD2 Antibody

Product Images

Western blot analysis of LEMD2 in 293 cell lysate with LEMD2 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunofluorescence of LEMD2 in 3T3 cells with LEMD2 antibody at 20 ug/mL.

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  Immunocytochemistry of LEMD2 in 3T3 cells with LEMD2 antibody at 2.5 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: LEMD2 antibody was raised against a 16 amino acid synthetic peptide near the center of human LEMD2.
• Formulation: LEMD2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: LEMD2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: LEM domain containing 2
• Database Link:
  NP_851853
  Entrez Gene 224640 MouseEntrez Gene 221496 Human
  UniProt ID Q8NC56
• Background: LEMD2 Antibody: The LEM (lamina-associated polypeptide-emerin-MAN1) domain is a motif shared by a group of lamin-interacting proteins of the inner nuclear membrane (INM) and nucleoplasm. One such protein, LEMD2 (LEM domain-containing protein 2), is a lamina-associated protein in the INM involved in nuclear structure organization, containing an N-terminal LEM motif, two transmembrane domains, and a MAN1-Src1p C-terminal (MSC) domain. LEMD2 is a truncated paralog of MAN1, lacking the MAN1-specific C-terminal RNA-recognition motif, but like MAN1 is required for myogenic differentiation. Mutations in LEMD2 are thought be among the possible causes of muscle disease.
• Synonyms: CTRCT42; dJ482C21.1; NET25

Reference Data

• Protein Families: Transmembrane