NLRP7 Rabbit Polyclonal Antibody

CAT#: TA320136

Rabbit Polyclonal NALP7 Antibody

Product Images

Western blot analysis of NALP7 in human brain tissue lysate with NALP7 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of NALP7 in human brain tissue with NALP7 antibody at 10 ug/mL.

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  Immunofluorescence of NALP7 in human brain tissue with NALP7 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: NALP7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NALP7.
• Formulation: NALP7 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: NALP7 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: NLR family, pyrin domain containing 7
• Database Link:
  NP_631915
  Entrez Gene 199713 Human
  UniProt ID Q8WX94
• Background: NALP7 Antibody: NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1β secretion and is a feedback regulator of interleukin-1β secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.
• Synonyms: CLR19.4; HYDM; NALP7; NOD12; PAN7; PYPAF3