NLRC3 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, WB |
|---|---|
| Recommended Dilution | WB: 1 - 2 ug/mL, IF: 20 ug/mL |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | NOD3 antibody was raised against an 18 amino acid synthetic peptide near the center of human NOD3. |
| Buffer | NOD3 Antibody is supplied in PBS containing 0.02% sodium azide. |
| Concentration | 1ug/ul |
| Purification | NOD3 Antibody is affinity chromatography purified via peptide column. |
| Conjugation | Unconjugated |
| Storage | Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | NLR family, CARD domain containing 3 |
| Database Link | |
| Background | NOD3 Antibody: NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-kappaB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells. |
| Synonyms | CLR16.2; NOD3 |
| Reference Data | |
| Protein Categories | Cytokines, Intracellular Proteins |
| Protein Families | Druggable Genome |
Reviews
Documents
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Citations
NLRC3 High Expression Represents a Novel Predictor for Positive Overall Survival Correlated With CCL5 and CXCL9 in HCC Patients
Wang, Shi, Xu et al
Front Oncol (2022) 12, 815326 DOI: 10.3389/fonc.2022.815326
Wang, Shi, Xu et al
Front Oncol (2022) 12, 815326 DOI: 10.3389/fonc.2022.815326
Cited by 12
AI Summary: OriGene's rabbit anti-NLRC3 antibody was used for multiple immunohistochemistry to evaluate NLRC3 expression levels in hepatocellular carcinoma tissue samples in this study.
Snippet: (0-3) or high (4-7). Multiple Immunohistochemistry Multiple immunohistochemistry (mIHC) was conducted by the Opal method on TMAs. Tissues were incubated with antibodies: rabbit anti-NLRC3 antibody (Origene, USA), rabbit anti-CD8 antibody (Abcam, UK), rabbit anti-CD11c antibody (Abcam, UK), et al. After a subsequent antigen retrieval, the nuclei were counterstained with DAPI at room temperature
Showing 1-1 of 1 papers.
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