GCOM1 (MYZAP) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | MYOZAP antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human MYOZAP. |
| Buffer | MYOZAP Antibody is supplied in PBS containing 0.02% sodium azide. |
| Concentration | 1ug/ul |
| Purification | MYOZAP Antibody is affinity chromatography purified via peptide column. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | myocardial zonula adherens protein |
| Database Link | |
| Background | MYOZAP Antibody: MYOZAP, also known as GRINL1A, is a 54 kDa highly conserved cardiac protein. It is strongly expressed in the heart and lung and is a novel component of intercalated disc. MYOZAP interacts with myosin phosphatase-RhoA interacting protein (MRIP) and acts as an activator of Rho-dependent SRF signaling. Knockdown study in zebrafish results in cardiomyopathy with severe dysfunction. The MYOZAP gene is part of a complex transcript unit that includes the gene for glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A (GRINL1A). Transcription of this gene occurs at an upstream promoter, with two different groups of alternatively spliced variants: Gup for GRINL1A upstream transcripts and Gcom for GRINL1A combined transcripts. |
| Synonyms | FLJ30973; Gcom2; GRINL1A; Gup1; Gup2; MGC126694; MGC138353 |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
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Citations
GRINL1A Complex Transcription Unit Containing GCOM1, MYZAP, and POLR2M Genes Associates with Fully Penetrant Recessive Dilated Cardiomyopathy
Heliö, Mäyränpää, Saarinen et al
Front Genet (2021) 12, 786705 DOI: 10.3389/fgene.2021.786705
Heliö, Mäyränpää, Saarinen et al
Front Genet (2021) 12, 786705 DOI: 10.3389/fgene.2021.786705
Cited by 15
AI Summary: OriGene products contributed to this study by providing the anti-GCOM1 antibody (OriGene, TA325524) used for immunohistochemical analysis of myocardial samples to assess GCOM1 protein expression in affected individuals.
Showing 1-1 of 1 papers.
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