TTYH2 Rabbit Polyclonal Antibody

CAT#: TA320078

Rabbit Polyclonal TTYH2 Antibody

Product Images

Western blot analysis of TTYH2 in human kidney tissue lysate with TTYH2 antibody at 1 ug/ml

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  Immunohistochemistry of TTYH2 in human kidney tissue with TTYH2 antibody at 2.5 ug/mL.

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  Immunofluorescence of TTYH2 in human kidney tissue with TTYH2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TTYH2 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human TTYH2.
• Formulation: TTYH2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: TTYH2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tweety family member 2
• Database Link:
  NP_116035
  Entrez Gene 117160 MouseEntrez Gene 287803 RatEntrez Gene 94015 Human
  UniProt ID Q9BSA4
• Background: TTYH2 Antibody: TTYH2 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions. TTYH2 is a Ca2+-activated large conductance chloride (Cl-) channel and may play a role in kidney tumorigenesis. It is also upregulated in colon carcinoma and is thought to play a role in cell proliferation and call aggregation, suggesting that TTYH2 may play a role in regulating both proliferation and metastatic potentials of colorectal cancer. The ubiquitin-protein ligase Nedd4-2 binds to and ubiquitinates TTYH2, thereby regulating its cell surface expression and total cellular levels.
• Synonyms: C17orf29

Reference Data

• Protein Families: Transmembrane