TMEM88 Rabbit Polyclonal Antibody

CAT#: TA320074

Rabbit Polyclonal TMEM88 Antibody

Product Images

Western blot analysis of TMEM88 in human brain tissue lysate with TMEM88 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of TMEM88 in mouse brain tissue with TMEM88 antibody at 2.5 ug/mL.

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  Immunofluorescence of TMEM88 in mouse brain tissue with TMEM88 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TMEM88 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human TMEM88.
• Formulation: TMEM88 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: TMEM88 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: transmembrane protein 88
• Database Link:
  NP_981956
  Entrez Gene 67020 MouseEntrez Gene 497936 RatEntrez Gene 92162 Human
  UniProt ID Q6PEY1
• Background: TMEM88 Antibody: Transmembrane protein 88 (TMEM88) is a two-transmembrane-type protein whose C-terminal tail has been shown to bind the PDZ domain of Dishevelled (Dvl), one of the key components in Wnt signaling pathways. TMEM88 attentuated the Wnt/beta-catenin signaling induced by Wnt-1 ligand in a dose-dependent manner and knockdown of TMEM88 by RNAi increased Wnt activity, suggesting that TMEM88 plays a role in regulating Wnt signaling in a context-dependent manner.
• Synonyms: FLJ20025; MGC71744

Reference Data

• Protein Families: Transmembrane