HHATL Rabbit Polyclonal Antibody

CAT#: TA319975

Rabbit Polyclonal HHATL Antibody

Product Images

Western blot analysis of HHATL in 3T3 cell lysate with HHATL antibody at 1 ug/mL.

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  Immunohistochemistry of HHATL in human skin tissue with HHATL antibody at 2.5 ug/mL.

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  Immunofluorescence of HHATL in human skin tissue with HHATL antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: HHATL antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human HHATL.
• Formulation: HHATL Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: HHATL Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: hedgehog acyltransferase-like
• Database Link:
  NP_065758
  Entrez Gene 74770 MouseEntrez Gene 301073 RatEntrez Gene 57467 Human
  UniProt ID Q9HCP6
• Background: HHATL Antibody: The Protein-cysteine N-palmitoyltransferase HHAT-like protein (HHATL), also known at the mammalian glycerol uptake/transporter 1 (Gup1) is a homolog of the S. cerevisiae Gup1. It is an endoplasmic reticulum (ER) membrane protein that co-localizes with the mammalian hedgehog acyltransferse Skn and interferes with its N-terminal palmitoylation of Sonic hedgehog (SHH), suggesting that HHATL acts as a negative regulator for N-terminal palmitoylation of SHH. HHATL is highly expressed in normal skin, but becomes down-regulated in skin squamous cell carcinoma, suggesting it may play a role in its development.
• Synonyms: C3orf3; GUP1; MBOAT3; MSTP002; OACT3

Reference Data

• Protein Families: Transmembrane