PIWIL2 Rabbit Polyclonal Antibody

CAT#: TA319953

Rabbit Polyclonal PIWI-L2 Antibody

Product Images

Immunohistochemistry of PIWI-L2 in human brain tissue with PIWI-L2 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 5 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PIWI-L2 antibody was raised against a 14 amino acid synthetic peptide near the center of human PIWI-L2.
• Formulation: PIWI-L2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: PIWI-L2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: piwi like RNA-mediated gene silencing 2
• Database Link:
  NP_060538
  Entrez Gene 55124 Human
  UniProt ID Q8TC59
• Background: PIWI-L2 Antibody: PIWI-L2 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L2 has been implicated in multiple roles including stem cell self-renewal and is highly expressed in many breast cancers. In these tumors, PIWI-L2 silences the expression of STAT3, a regulator of Bcl-XL and cyclin D1, allowing the proliferation and survival of breast cancer stem cells. Recent studies have shown that overexpression of PIWI-like proteins are potential biomarkers for colon and other cancers.
• Synonyms: CT80; HILI; mili; PIWIL1L

Reference Data

• Protein Pathways: Dorso-ventral axis formation