PIWIL2 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, WB |
|---|---|
| Recommended Dilution | WB: 1 ug/mL |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | PIWI-L2 antibody was raised against a 17 amino acid synthetic peptide near the center of human PIWI-L2. |
| Buffer | PIWI-L2 Antibody is supplied in PBS containing 0.02% sodium azide. |
| Concentration | 1ug/ul |
| Purification | PIWI-L2 Antibody is affinity chromatography purified via peptide column. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | piwi like RNA-mediated gene silencing 2 |
| Database Link | |
| Background | PIWI-L2 Antibody: PIWI-L2 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L2 has been implicated in multiple roles including stem cell self-renewal and is highly expressed in many breast cancers. In these tumors, PIWI-L2 silences the expression of STAT3, a regulator of Bcl-XL and cyclin D1, allowing the proliferation and survival of breast cancer stem cells. Recent studies have shown that overexpression of PIWI-like proteins are potential biomarkers for colon and other cancers. |
| Synonyms | CT80; HILI; mili; PIWIL1L |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Pathways | Dorso-ventral axis formation |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Glucocorticoid Receptor Signaling in the Mammalian Germline
Cincotta
Thesis (2022)
Cincotta
Thesis (2022)
Snippet: HILI Origene TA319952 1:500 Tris-EdDTA ph8.8
Showing 1-1 of 1 papers.
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