WAC Rabbit Polyclonal Antibody

CAT#: TA319920

Rabbit Polyclonal WAC Antibody

Product Images

Western blot analysis of WAC in human testis tissue lysate with WAC antibody at 1 ug/mL.

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  Immunohistochemistry of WAC in mouse testis tissue with WAC antibody at 2.5 ug/mL.

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  Immunofluorescence of WAC in mouse testis tissue with WAC antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: WAC antibody was raised against a 19 amino acid peptide near the center of human WAC .
• Formulation: WAC Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: WAC Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 71 kDa; Observed: 75 kDa
• Gene Name: WW domain containing adaptor with coiled-coil
• Database Link:
  NP_057712
  Entrez Gene 225131 MouseEntrez Gene 307029 RatEntrez Gene 51322 Human
  UniProt ID Q9BTA9
• Background: WAC Antibody: The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.
• Synonyms: BM-016; DESSH; PRO1741; Wwp4