WAC Rabbit Polyclonal Antibody

SKU TA319920

Rabbit Polyclonal WAC Antibody

Product Data

• Application: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: WAC antibody was raised against a 19 amino acid peptide near the center of human WAC .
• Buffer: WAC Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: WAC Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: Predicted: 71 kDa; Observed: 75 kDa
• Gene Name: WW domain containing adaptor with coiled-coil
• Database Link:
  NP_057712
  Q9BTA9
• Background: WAC Antibody: The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.
• Synonyms: BM-016; DESSH; PRO1741; Wwp4

Reference Data