ZNF281 Rabbit Polyclonal Antibody

CAT#: TA319862

Rabbit Polyclonal ZFP281 Antibody

Product Images

Western blot analysis of ZFP281 in A-20 cell lysate with ZFP281 antibody at (A) 0.25 and (B) 0.5 ug/mL.

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  Immunofluorescence of ZFP291 in A20 cells with ZFP291 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 0.25 - 0.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ZFP281 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human ZFP281.
• Formulation: ZFP281 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: ZFP281 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: zinc finger protein 281
• Database Link:
  AAH51905
  Entrez Gene 23528 Human
  UniProt ID Q9Y2X9
• Background: ZFP281 Antibody: ZFP281, also known as ZBP-99, is a member of a conserved family of transcription factors that interact with GC-rich promoters. It contains four Kruppel-like zinc fingers and is highly homologous to ZBP-89, another regulator of ornithine decarboxylase gene expression. ZFP281 also interacts with many other other transcription factors, such as Sp1 to repress vimentin gene transcription. ZFP281 has also been shown to control embryonic stem cell pluripotency by direct regulating specific target genes. ZFP281 phyically interacts with the transcription factos POU5F1, Sox2, and NANOG. Gene expression microarray anlysis indicated that some ZFP281 target genes were activated, while others were repressed upon knockdown of ZFP281 expression, showing that ZFP281 plays bifuctinal roles in regulating gene expression in stem cells.
• Synonyms: ZBP-99; ZNP-99