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KDM6B Rabbit Polyclonal Antibody

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SKU
TA319844
Rabbit Polyclonal JMJD3 Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $640.00
2 Weeks*
Bulk/Customize

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View other "KDM6B or NM_001080424" antibodies

Specifications
Specifications
Product Data
Application IF, WB
Recommended Dilution WB: 0.5 ug/mL, IF: 5 ug/mL
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen JMJD3 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human JMJD3.
Buffer JMJD3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification JMJD3 Antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name lysine demethylase 6B
Database Link
Background JMJD3 Antibody: The Jumonji domain-containing protein 3 (JMJD3) functions as a trimethylation-specific demethylase, converting the trimethylated histone H3 Lys27 residue to the dimethylated form, and is thought to also function as a transcriptional repressor. JMJD3 plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. JMJD3 can also interact with and demethylate p53, resulting in its stabilization and localization to the nucleus in mouse embryo fibroblasts during neural stem cell differentiation.
Synonyms JMJD3
Reference Data
Protein Categories Intracellular Proteins
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Documents
Resources

file-alt Citations

Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways
Johnstone, Andrade, Barbier et al
Addict Biol (2019)
AI Summary: OriGene’s KDM6B overexpression plasmid was used to increase KDM6B levels in BV-2 cells, enabling the study of how altered KDM6B expression affects inflammatory signaling pathways in the context of alcohol dependence.
Snippet: then collected for RNA isolation. Overexpression of KDM6B in BV‐2 cells was achieved using a plasmid (OriGene, Rockville, MD, USA) and Lipofectamine 2000 CD (Invitrogen, Carlsbad, CA, USA). KDM6B knockout cell lines
ChIP
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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