DIS3 Rabbit Polyclonal Antibody

CAT#: TA319839

Rabbit Polyclonal DIS3 Antibody

Product Images

Western blot analysis of DIS3 in human ovary tissue lysate with DIS3 antibody at 1 ug/mL.

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  Immunohistochemistry of DIS3 in mouse testis tissue with DIS3 antibody at 2.5 ug/mL.

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  Immunofluorescence of DIS3 in mouse testis tissue with DIS3 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DIS3 antibody was raised against an 18 amino acid peptide near the amino terminus of human DIS3.
• Formulation: DIS3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: DIS3 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 105 kDa; Observed: 103 kDa
• Gene Name: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
• Database Link:
  NP_055768
  Entrez Gene 72662 MouseEntrez Gene 306103 RatEntrez Gene 22894 Human
  UniProt ID Q9Y2L1
• Background: DIS3 Antibody: The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.
• Synonyms: 2810028N01Rik; dis3p; EXOSC11; KIAA1008; RRP44

Reference Data

• Protein Pathways: RNA degradation