Klotho(KL) Rabbit Polyclonal Antibody

CAT#: TA319778

Rabbit Polyclonal KLOTHO Antibody

Antibody Service


 Product Datasheet for 'TA319778'

USD 371


Availability*
In Stock

Size
    • 100 ug

Product images

Specifications

Product Data
Clone Name Polyclonal
Applications WB, IHC, IF
Recommend Dilution WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen KLOTHO antibody was raised against a 16 amino acid synthetic peptide near the center of human KLOTHO.
Isotype IgG
Formulation KLOTHO Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1mg/ml
Purification KLOTHO Antibody is affinity chromatography purified via peptide column.
Gene Name klotho
Background KLOTHO Antibody: KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
Synonyms -
Reference Data
Protein Families Secreted Protein, Transmembrane
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.