LIF Rabbit Polyclonal Antibody

CAT#: TA319675

Rabbit Polyclonal LIF Antibody

Product Images

Western blot analysis of LIF in 3T3 cell lysate with LIF antibody at (A) 1 and (B) 2 ug/mL.

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  Immunofluorescence of LIF in 3T3 cells with LIF antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: LIF antibody was raised against a 16 amino acid synthetic peptide near the center of human LIF.
• Formulation: LIF Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: LIF Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: leukemia inhibitory factor
• Database Link:
  NP_002300
  Entrez Gene 16878 MouseEntrez Gene 60584 RatEntrez Gene 3976 Human
  UniProt ID P15018
• Background: LIF Antibody: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. LIF was initially recognized by its ability to induce terminal differentiation of myeloid leukemic cells. It is a member of the IL-6 cytokine superfamily and can be highly glycosylated. LIF signaling is transduced through the LIF-R/gp130 receptor complex, leading to the phosphorylation and activation of the JAK/STAT pathway. Recent evidence shows that LIF inhibits cardiomyogenesis in embryonic stem cells via STAT3 activation.
• Synonyms: CDF; DIA; HILDA; MLPLI

Reference Data

• Protein Families: Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway