DPAGT1 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | DPAGT1 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human DPAGT1. |
| Buffer | DPAGT1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| Concentration | 1ug/ul |
| Purification | DPAGT1 Antibody is affinity chromatography purified via peptide column. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 |
| Database Link | |
| Background | DPAGT1 Antibody: The UDP-N-acetylglucosamine-dolichyl-phosphate N-acetyl-glucosaminephosphotransferase (DPAGT1) is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. Mutations in this integral endoplasmic reticulum (ER) membrane protein enzyme belongs to the glycosyltransferase family 4 results in the congenital disorder of glycosylation type Ij with symptoms such as severe hypotonia, medically intractable seizures, mental retardation, microcephaly, and exotropia. Recent experiments have shown that DPAGT1 is a target of the Wnt/beta-catenin signaling pathway, with Wnt3a inducing higher DPAGT1 mRNA expression. |
| Synonyms | ALG7; CDG-Ij; CDG1J; CMSTA2; D11S366; DGPT; DPAGT; DPAGT2; G1PT; GPT; UAGT; UGAT |
| Reference Data | |
| Protein Categories | Membrane Proteins, Nervous system Diseases |
| Protein Families | Transmembrane |
| Protein Pathways | Metabolic pathways, N-Glycan biosynthesis |
Reviews
Documents
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| FAQs |
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Citations
The role of Alg13 N-acetylglucosaminyl transferase in the expression of pathogenic features of Candida albicans
Niewiadomska, Janik, Perlińska-Lenart et al
Biochim. Biophys. Acta (2017) 1861 (4), 789-801 DOI: 10.1016/j.bbagen.2017.01.019
Niewiadomska, Janik, Perlińska-Lenart et al
Biochim. Biophys. Acta (2017) 1861 (4), 789-801 DOI: 10.1016/j.bbagen.2017.01.019
Snippet: 2.8. Immunodetection of Alg7 protein. Total membrane fraction use for activity assay was also examined for the amount of the Alg7 protein by immunostaining with monoclonal antibody against human Alg7p (OriGene, Herford, Germany). ... Cite SaveSaving
Showing 1-1 of 1 papers.
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