Il6 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | ELISA, IHC, WB |
|---|---|
| Recommended Dilution | WB: 1:1000 IHC: User Optimized ELISA: 1:10,000 |
| Reactivity | Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Anti-IL-6 is an IgG fraction antibody prepared from rabbit antiserum after repeated immunizations with recombinant mouse IL-6 protein produced in E.coli. |
| Specificity | This product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. This antibody is specific for mouse IL-6 protein. A BLAST analysis was used to suggest cross-reactivity with IL-6 from mouse sources based on 100% homology with the immunizing sequence. Cross-reactivity with IL-6 from other sources has not been determined. |
| Buffer | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 Stabilizer: None Preservative: None |
| Reconstitution Method | Restore with deionized water (or equivalent) - Reconstitution Volume: 100 µL |
| Concentration | 1.0 mg/mL - lot specific |
| Conjugation | Unconjugated |
| Storage | Store anti-IL-6 at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. |
| Stability | Expiration date is six (6) months from date of receipt. |
| Shipping | Ambient |
| Gene Name | interleukin 6 |
| Database Link | |
| Background | Interleukin (IL)-6, also know as BCDG, BCGF and BSF-2, is an important proinflammatory and immunoregulatory cytokine expressed by various cells. Interleukin-6 has been shown to inhibit the growth of early stage and to promote the proliferation of advanced stage melanoma cells in vitro. Anti-IL-6 antibody is ideal for investigators involved in Cancer, Neuroscience and Immunology research. |
| Synonyms | rabbit anti-IL-6 antibody, rabbit anti-Interleukin-6 antibody, Interleukin6 cytokine, IL6, B-cell stimulatory factor 2, BSF-2, Interferon beta-2, IFN-beta-2, Hybridoma growth factor, CTL differentiation factor, CDF, Interleukin HP-1 |
| Note | This purified antibody has been tested for use in western blotting against recombinant mouse IL-6 spiked into cell lysates. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 21.7 kDa in size corresponding to the mature 187 amino acid mouse IL-6 protein by western blotting in appropriate cell lysates or extracts. |
| Reference Data | |
Reviews
Documents
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Citations
Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction
Jang, Lee, Park et al
Front Pharmacol (2019) 10, 892 DOI: 10.3389/fphar.2019.00892
Jang, Lee, Park et al
Front Pharmacol (2019) 10, 892 DOI: 10.3389/fphar.2019.00892
AI Summary: In the paper "Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction," OriGene products, specifically the anti-mouse interleukin-6 (IL-6) antibody, were used to assess inflammatory cytokine expression, contributing to the evaluation of baicalein’s therapeutic effects on radiation-induced intestinal inflammation.
Snippet: anti-mouse zonula occludens-1 (ZO-1;Abcam, Cambridge, UK), anti-mouse P-selectin (Santacruz, Dallas, TX, USA), anti-mouse myeloperoxidase (MPO), anti-neutrophil elastase (Abcam), anti-mouse interleukin-6 (IL-6), and anti-mouse Ki-67 (Acris Antibodies GmbH Cached
Showing 1-1 of 1 papers.
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