TRAF2 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | ELISA, IF, WB |
|---|---|
| Recommended Dilution | WB: 1 µg/mL IF: User Optimized ELISA: 1:60,000 - 1:250,000 |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region human TRAF2. |
| Specificity | This affinity purified antibody is directed against human TRAF2 protein. The product was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody is predicted to react with TRAF2 from human and mouse sources based on a 100% homology with the immunizing sequence. Reactivity with TRAF2 from other sources has not been determined. |
| Buffer | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 Stabilizer: None Preservative: 0.01% (w/v) Sodium Azide |
| Concentration | 0.93 mg/mL - lot specific |
| Conjugation | Unconjugated |
| Storage | Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. |
| Stability | Expiration date is one (1) year from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | TNF receptor associated factor 2 |
| Database Link | |
| Background | TRAF2, or Tumor Necrosis factor (TNF) Receptor-Associated Factor 2, is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Association to the receptor is also mediated by the interaction with TRADD. TRAF2 mediates activation of NF-kappa-B and MAPK8/JNK and is involved in apoptosis. TRAF2 forms a heterodimeric complex with TRAF1, which then recruits the inhibitor-of-apoptosis proteins (IAPs), apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 for the inhibition of caspase activation. In this way it functions as a mediator of the anti-apoptotic signals from TNF receptors. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. TRAF2 may be involved in IL-15 signaling. Multiple alternatively spliced transcript variants exist, but the biological validity of only one transcript has been determined. |
| Synonyms | rabbit anti-TRAF2 antibody, E3 ubiquitin-protein ligase TRAF2, RING-type E3 ubiquitin transferase TRAF2, TNF receptor associated factor 2 antibody, TRAF-2, TRAF 2 antibody, TRAP-3, TRAP 3 antibody, TRAP3 antibody, Tumor necrosis factor type 2 receptor associated protein 3 antibody |
| Note | Rabbit Anti-TRAF2 Antibody has been tested in ELISA and Western Blot. Positive control HeLa Whole Cell lysate (p/n W09-000-364) expect ~47kDa. Specific conditions for reactivity should be optimized by the end user. |
| Reference Data | |
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Citations
RIG-I Promotes Cell Death in Hepatocellular Carcinoma by Inducing M1 Polarization of Perineal Macrophages Through the RIG-I/MAVS/NF-κB Pathway
Zhou, Li, Yang et al
OncoTargets and therapy (2020) 13, 8783-8794 DOI: 10.2147/OTT.S258450
Zhou, Li, Yang et al
OncoTargets and therapy (2020) 13, 8783-8794 DOI: 10.2147/OTT.S258450
AI Summary: OriGene products, including the Ddx58 (NM_172689) Mouse Tagged ORF Clone Lentiviral Particle (CAT#: MR226477L4V), Lenti ORF control particles of pLenti-C-mGFP-P2A-Puro (CAT#: PS100093V), and TA310155, were used for RIG-I overexpression and as experimental controls to investigate the role of RIG-I in macrophage polarization and hepatocellular carcinoma cell death.
Snippet: Ddx58 (NM_172689) Mouse Tagged ORF Clone Lentiviral Particle (CAT＃: MR226477L4V) and Lenti ORF control particles of pLenti-C-mGFP-P2A-Puro (CAT＃: PS100093V) were purchased from Origene Corporation No. TA310155) was obtained from OriGene
Showing 1-1 of 1 papers.
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