Cdkn2a Goat Polyclonal Antibody

CAT#: TA309548

Goat Polyclonal Antibody against P19ARF (mouse)

Product Images

TA309548 (0.3ug/ml) staining of Mouse Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 0.3-1ug/ml
• Reactivities: Mouse
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Peptide with sequence C-RRGPHRNPGPGDDD, from the internal region of the protein sequence according to NP_034007.1.
• Formulation: Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cyclin-dependent kinase inhibitor 2A
• Database Link:
  NP_034007
  Entrez Gene 12578 Mouse
  UniProt ID Q64364
• Background: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq]
• Synonyms: ARF; CDK4I; CDKN2; CMM2; INK4; INK4a; MLM; MTS-1; MTS1; OTTHUMP00000021148; p14; p14ARF; p16; p16-INK4; p16-INK4a; p16INK4; p16INK4a; p19; p19Arf; TP16