TLR4 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | FC, IHC, ICC, WB |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Developed against a synthetic peptide corresponding to amino acids 420-435 of human TLR4. |
| Buffer | PBS pH7.4, 50% glycerol |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | toll like receptor 4 |
| Database Link | |
| Background | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. provided by RefSeq |
| Synonyms | ARMD10; CD284; TLR-4; TOLL |
| Reference Data | |
| Protein Categories | CD Markers, Chemokines, Cytokines, Growth Factors, Intracellular Proteins, Membrane Proteins, Nervous system Diseases |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Expression of Toll‑like receptor 4 on mast cells in gingival tissues of human chronic periodontitis
Huang, Dai, Huang
Mol Med Rep (2018)
Huang, Dai, Huang
Mol Med Rep (2018)
AI Summary: OriGene products contributed to this study by providing the anti-TLR4 antibody (TA309486), the DAB staining kit, and the PV9002 detection kit, which were used for immunohistochemical and immunofluorescence analyses to detect TLR4 expression in gingival tissues and mast cells.
Snippet: no. PV9002;OriGene Technologies, Beijing, China), applied the DAB (DAB staining kit;OriGene Technologies) as the chromogenic reagents and substituted the I-antibody with PBS as the negative control no. TA309486, OriGene Technologies) was 1:100
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