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UNC13B Rabbit Polyclonal Antibody

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SKU
TA308990
Rabbit Polyclonal antibody to UNC13B (unc-13 homolog B (C. elegans))
Size:
100 ul
Conjugation:
Unconjugated
  $665.00
5 Days*
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Specifications
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity Bovine), Human (Predicted: Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant fragment corresponding to a region within amino acids 680 and 957 of UNC13B (Uniprot ID#O14795)
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration lot specific
Purification Purified by antigen-affinity chromatography.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 181 kDa
Gene Name unc-13 homolog B (C. elegans)
Database Link
Background This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. provided by RefSeq
Synonyms MUNC13; UNC13; Unc13h2
Note Seq homology of immunogen across species: Mouse (99%), Rat (98%), Bovine (99%)
Reference Data
Protein Categories Intracellular Proteins
Protein Families Druggable Genome
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Documents
Resources

file-alt Citations

Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons
Liang, Xue, Xue et al
Protein Cell (2021)
Cited by 34
AI Summary: OriGene products, specifically the UNC13B antibody (TA308990), were used for immunohistochemistry and immunocytochemistry to help identify neuronal markers in sinoatrial node pacemaker cells, supporting the study's findings of glutamatergic neuron-like properties in these heart cells.
Snippet: UNC13B (1:50 for immunohistochemistry, 1:100 for immunocytochemistry, TA308990, Origene), SNAP25 (1:50 for immunohistochemistry,
IHC ICC
Showing 1-1 of 1 papers.
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