GLDC Rabbit Polyclonal Antibody
SKU
TA308885
Rabbit Polyclonal antibody to Glycine dehydrogenase (glycine dehydrogenase (decarboxylating))
$665.00
2 Weeks*
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000 |
| Reactivity | Bovine), Chicken, Human (Predicted: Mouse, Rat, Xenopus |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 442 and 723 of Glycine dehydrogenase (Uniprot ID#P23378) |
| Buffer | 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative. |
| Purification | Purified by antigen-affinity chromatography. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 113 kDa |
| Gene Name | glycine decarboxylase |
| Database Link | |
| Background | The enzyme system for cleavage of glycine (glycine cleavage system; GCS; EC 2.1.2.10), which is confined to the mitochondria, is composed of 4 protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). Glycine encephalopathy (GCE; MIM 605899) may be due to a defect in any one of these enzymes; see MIM 238310, MIM 238330, and MIM 238331. supplied by OMIM |
| Synonyms | GCE; GCSP; HYGN1 |
| Note | Seq homology of immunogen across species: Mouse (91%), Chicken (85%), Rat (84%), Xenopus laevis (86%), Bovine (92%) |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Glycine, Metabolic pathways, serine and threonine metabolism |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Nonketotic hyperglycinemia: Functional assessment of missense variants in GLDC to understand phenotypes of the disease
Bravo-Alonso, Navarrete, Arribas-Carreira et al
Hum. Mutat. (2017)
Bravo-Alonso, Navarrete, Arribas-Carreira et al
Hum. Mutat. (2017)
AI Summary: In this study, the human GLDC gene cloned in the pCMV6-XL4 plasmid from OriGene was used to generate mutant constructs for functional analysis of GLDC missense variants associated with nonketotic hyperglycinemia.
Snippet: The full-length open reading frame of human GLDC was cloned into the mammalian pCMV plasmid -pCMV6-XL4- (OriGene Technologies, Rockville, MD), and was used to generate recombinant plasmids for each mutation using the QuickChange site-directed mutagenesis ... All 2 versions Cite SaveSaving
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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