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CD41 (ITGA2B) Rabbit Polyclonal Antibody

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SKU
TA308579
Rabbit polyclonal antibody to CD41/Integrin alpha 2b (integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41))
Size:
100 ul
Conjugation:
Unconjugated
  $665.00
5 Days*
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View other "CD41 or NM_000419" antibodies

Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity Bovine), Human (Predicted: Dog
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant fragment corresponding to a region within amino acids 210 and 532 of Integrin alpha 2b (Uniprot ID#P08514)
Buffer 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Concentration lot specific
Purification Purified by antigen-affinity chromatography.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 113 kDa
Gene Name integrin subunit alpha 2b
Database Link
Background ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. provided by RefSeq
Synonyms BDPLT2; BDPLT16; CD41; CD41B; GP2B; GPIIb; GT; GTA; HPA3; PPP1R93
Note Seq homology of immunogen across species: Dog (88%), Bovine (86%)
Reference Data
Protein Categories Cardiovascular diseases, CD Markers, Intracellular Proteins, Membrane Proteins
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer
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Documents
Resources

file-alt Citations

αvβ3 integrin expression increases elasticity in human melanoma cells
Lacaria, Lange, Goldmann et al
Biochem. Biophys. Res. Commun. (2020) 525 (4), 836-840 DOI: 10.1016/j.bbrc.2020.02.156
Cited by 18
AI Summary: OriGene contributed to this study by providing the mouse monoclonal antibody for the β3 integrin subunit, which was used to investigate the role of αvβ3 integrin in regulating the mechanical properties of human melanoma cells.
Snippet: purchased from Millipore-Sigma. Specific mouse monoclonal antibodies for β3 (BV3) and αIIb (B9) subunits were bought at Origene (Rockville, MD) and Santa Cruz Biotechnology (Dallas, TX), respectively. The APC-labeled
FC
Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with Kit(Wv) Mutations
Yurino, Takenaka, Yamauchi et al
Stem Cell Reports (2016)
Cited by 40
AI Summary: OriGene’s rabbit anti-human CD41 (EPR4330) antibody was used for immunohistochemical analysis to identify human platelet lineage cells in the study.
Snippet: For immunohistochemical analysis, rabbit anti-human CD41 (EPR4330;Origene) and glycophorin A/CD235a (EPR8199;Abcam) monoclonal antibodies, and rabbit anti-human hemoglobin subunit alpha polyclonal antibody (Abcam) were used
IHC
Showing 1-2 of 2 papers.
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