FPGT Rabbit Polyclonal Antibody

CAT#: TA308488

Rabbit polyclonal antibody to FPGT (fucose-1-phosphate guanylyltransferase)

Product Images

Sample (30 ug of whole cell lysate). A:Raji. 7.5% SDS PAGE. TA308488 diluted at 1:500

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  Immunohistochemical analysis of paraffin-embedded MDA-MB-468 xenograft, using FPGT (TA308488) antibody at 1:100 dilution.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human (Predicted: Dog, Monkey, Pig, Rabbit, Bovine)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 146 and 453 of FPGT (Uniprot ID#O14772)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 67 kDa
• Gene Name: fucose-1-phosphate guanylyltransferase
• Database Link:
  NP_003829
  Entrez Gene 100533995 DogEntrez Gene 100533986 MonkeyEntrez Gene 8790 Human
  UniProt ID O14772
• Background: L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. [provided by RefSeq]
• Synonyms: GFPP
• Note: Seq homology of immunogen across species: Dog (83%), Monkey (96%), Pig (84%), Rabbit (82%), Bovine (82%)

Reference Data

• Protein Pathways: Amino sugar and nucleotide sugar metabolism, Fructose and mannose metabolism, Metabolic pathways