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GALNS Rabbit Polyclonal Antibody

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SKU
TA308487
Rabbit Polyclonal antibody to GALNS (galactosamine (N-acetyl)-6-sulfate sulfatase)
Size:
100 ul
Conjugation:
Unconjugated
  $665.00
2 Weeks*
Bulk/Customize

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View other "GALNS or NM_000512" antibodies

Specifications
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant protein fragment contain a sequence corresponding to a region within amino acids 20 and 259 of GALNS
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration lot specific
Purification Purified by antigen-affinity chromatography.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 58 kDa
Gene Name galactosamine (N-acetyl)-6-sulfatase
Database Link
Background This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder. provided by RefSeq
Synonyms GalN6S; GALNAC6S; GAS; MPS4A
Reference Data
Protein Categories Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways Glycosaminoglycan degradation, Lysosome, Metabolic pathways
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Documents
Resources

file-alt Citations

Chondroitin sulfatases differentially regulate Wnt signaling in prostate stem cells through effects on SHP2, phospho-ERK1/2, and Dickkopf Wnt signaling pathway inhibitor (DKK3)
Bhattacharyya, Feferman, Tobacman
Oncotarget (2017) 8 (59), 100242-100260 DOI: 10.18632/oncotarget.22152
Snippet: Cells were silenced for either ARSB (EC 3.1.6.12) or GALNS (EC 3.1.6.4) by specific siRNA (Qiagen, Germantown, MD) (see below). Overexpression of ARSB (NCBI NM_000046, transcript variant 1;TrueClone, OriGene, Rockville, MD) or of GALNS (NCBI NM_000512;TrueClone, Origene) was performed by transfection of specific untagged plasmids (see below), as previously [57]
FigureFigureFigure
Showing 1-1 of 1 papers.
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