GALNS Rabbit Polyclonal Antibody

CAT#: TA308487

Rabbit Polyclonal antibody to GALNS (galactosamine (N-acetyl)-6-sulfate sulfatase)

Product Images

Sample (30 ug of whole cell lysate). A: H1299. 7.5% SDS PAGE. TA308487 diluted at 1:1000

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  GALNS antibody detects GALNS protein by Western blot analysis. A. 30 ug Neuro2A whole cell lysate/extract. B. 30 ug C2C12 whole cell lysate/extract. 7.5 % SDS-PAGE. GALNS antibody (TA308487) dilution: 1:1000

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  GALNS antibody detects GALNS protein by Western blot analysis. A. 30 ug PC-12 whole cell lysate/extract. B. 30 ug Rat2 whole cell lysate/extract. 7.5 % SDS-PAGE. GALNS antibody (TA308487) dilution: 1:500

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  Immunohistochemical analysis of paraffin-embedded NCI-N87 xenograft, using GALNS (TA308487) antibody at 1:100 dilution.

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  Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using GALNS (TA308487) antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with anti-alpha tubulin antibody (Red) at 1:500.

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 20 and 259 of GALNS
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 58 kDa
• Gene Name: galactosamine (N-acetyl)-6-sulfatase
• Database Link:
  NP_000503
  Entrez Gene 2588 Human
  UniProt ID P34059
• Background: This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder. [provided by RefSeq]
• Synonyms: GalN6S; GALNAC6S; GAS; MPS4A

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Glycosaminoglycan degradation, Lysosome, Metabolic pathways