BCL2L10 Rabbit Polyclonal Antibody

CAT#: TA308442

Rabbit polyclonal antibody to Bcl-B (BCL2-like 10 (apoptosis facilitator))

Product Images

Sample (30 ug of whole cell lysate). A: Raji. 12% SDS PAGE. TA308442 diluted at 1:1000.

• 

  Immunohistochemical analysis of paraffin-embedded A549 Xenograft, using BCL2L10 (TA308442) antibody at 1:100 dilution.

• 

  Immunofluorescence analysis of paraformaldehyde-fixed A431, using BCL2L10 (TA308442) antibody at 1:200 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 60 and 153 of BCL2L10 (Uniprot ID#Q9HD36)
• Formulation: 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 23 kDa
• Gene Name: BCL2 like 10
• Database Link:
  NP_065129
  Entrez Gene 10017 Human
  UniProt ID Q9HD36
• Background: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq]
• Synonyms: BCL-B; Boo; Diva

Reference Data

• Protein Families: Druggable Genome, Transmembrane