STAR Rabbit Polyclonal Antibody

CAT#: TA308393

Rabbit Polyclonal antibody to STAR (steroidogenic acute regulatory protein)

Product Images

Sample (50 ug of whole cell lysate). A: Mouse liver. 12% SDS PAGE. TA308393 diluted at 1:500.

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  Sample (30 ug of whole cell lysate). A: Molt-4. 12% SDS PAGE. TA308393 diluted at 1:1000.

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  STAR antibody detects STAR protein at cytosol on hepatoma by immunohistochemical analysis. Sample: Paraffin-embedded hepatoma. STAR antibody (TA308393) dilution: 1:500.

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  STAR antibody detects STAR protein at mitochondria by immunofluorescent analysis. Sample: HepG2 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: STAR protein stained by STAR antibody (TA308393) diluted at 1:500. Blue: Hoechst 33342 stainin

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human, Mouse (Predicted: Feline, Dog, Pig, Bovine)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 15 and 268 of STAR (Uniprot ID#P49675)
• Formulation: 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 32 kDa
• Gene Name: steroidogenic acute regulatory protein
• Database Link:
  NP_001007244
  Entrez Gene 20845 MouseEntrez Gene 475588 DogEntrez Gene 6770 Human
  UniProt ID P49675
• Background: The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq]
• Synonyms: cholesterol trafficker; mitochondrial steroid acute regulatory protein; StAR-related lipid transfer (START) domain containing 1; STARD1; START domain containing 1; steroid acute regulatory protein; steroidogenic acute regula; steroidogenic acute regulator
• Note: Seq homology of immunogen across species: Cat (89%), Dog (93%), Pig (90%), Bovine (87%)

Reference Data

• Protein Families: Druggable Genome