GALR2 Rabbit Polyclonal Antibody

CAT#: TA308348

Rabbit polyclonal antibody to galanin receptor 2 (galanin receptor 2)

Product Images

Sample (30 ug of whole cell lysate). A:A431. 12% SDS PAGE. TA308348 diluted at 1:500

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  Galanin Receptor 2 antibody detects GALR2 protein at membrane on Cal27 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded Cal27 xenograft. Galanin Receptor 2 antibody (TA308348) dilution: 1:500.

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  Galanin Receptor 2 antibody detects Galanin Receptor 2 protein at membrane and cytosol on rat fore brain by immunohistochemical analysis. Sample: Paraffin-embedded rat fore brain. Galanin Receptor 2 antibody (TA308348) dilution: 1:500.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human (Predicted: Bovine, Chicken, Mouse)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 243 and 336 of Galanin Receptor 2 (Uniprot ID#O43603)
• Formulation: 1XPBS, 50% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 42 kDa
• Gene Name: galanin receptor 2
• Database Link:
  NP_003848
  Entrez Gene 14428 MouseEntrez Gene 8811 Human
  UniProt ID O43603
• Background: Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq]
• Synonyms: GAL2-R; GALNR2; GALR-2
• Note: Seq homology of immunogen across species: Mouse (92%), Chicken (86%), Bovine (93%)

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction